Disable Oracle APPS Responsiblity from backend on R12

Please make sure that you are working on Oracle R12 because this may be different in Oracle 11i

Find out responsibility for the user you want to disable.

End date the below table for that user and responsibility

WF_USER_ROLE_ASSIGNMENTS.end_date

You can analyse below view to know more about it.

FND_USER_RESP_GROUPS (View)